In Romania, modafinil is assessed as a stimulant doping agent and it is prohibited in sports activities competitions.

Table one presents the adverse reactions that transpired in a fee of one% or even more and were being additional Repeated in PROVIGIL-taken care of patients than in placebo-dealt with sufferers during the placebo-managed scientific trials.

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Modafinil may be practice-forming. Never share Provigil with Yet another person, Particularly another person using a record of drug abuse or dependancy. Keep the medication in a location where Other individuals are unable to get to it. Advertising or giving freely this medicine is in opposition to the legislation.

Provigil is utilised to treat extreme sleepiness brought on by snooze apnea, narcolepsy, or change operate sleep ailment.

Indicated to boost wakefulness in Older people with too much sleepiness connected with obstructive rest apnea (OSA)

sparsentan will reduce the level or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and minimizes efficacy associated with these substrates.

Geriatric Use: In aged people, modafinil and metabolite elimination is likely to modafinil dosage be decreased, so consider using decreased doses and intently keep track of patients.

stiripentol will enhance the degree or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Carefully. Consider lessening the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.

modafinil will improve the stage or influence of diazepam intranasal by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Potent or average CYP2C19 inhibitors may perhaps minimize rate of diazepam elimination, thus raising adverse reactions to diazepam.

Modafinil wasn't observed to promote overuse or misuse, even in Individuals who have a historical past of cocaine addiction.[a hundred and fifteen] Regardless of the initial perception that modafinil carried no abuse likely, emerging proof indicates that it works at the exact same neurobiological mechanisms as other addictive stimulants.

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In cases exactly where steady optimistic airway strain (CPAP) may be the treatment method of option for abnormal sleepiness, a maximal hard work to deal with with CPAP for an ample stretch of time must be designed previous to initiating this drug.

Furthermore, quite a few intentional acute overdoses occurred; the two major becoming 4500 mg and 4000 mg taken by two topics taking part in foreign depression scientific tests. None of such research subjects expert any unexpected or existence-threatening outcomes. Adverse reactions which were reported at these doses incorporated excitation or agitation, sleeplessness, and slight or average elevations in hemodynamic parameters.